Positioning cytokinesis

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Positioning cytokinesis.

Cytokinesis is the terminal step of the cell cycle during which a mother cell divides into daughter cells. Often, the machinery of cytokinesis is positioned in such a way that daughter cells are born roughly equal in size. However, in many specialized cell types or under certain environmental conditions, the cell division machinery is placed at nonmedial positions to produce daughter cells of d...

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Endosome positioning during cytokinesis.

In mammalian cells, completion of cytokinesis relies on targeted delivery of recycling membranes to the midbody. At this step of mitosis, recycling endosomes are organized as clusters located at the mitotic spindle poles as well as at both sides of the midbody. However, the mechanism that controls endosome positioning during cytokinesis is not known. Here, we discuss the possible mechanisms tha...

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Cytokinesis: The Ubc of Positioning

A recent analysis of spindle positioning in yeast sheds light on how interactions between microtubules and the cleavage apparatus are modulated through mitosis to promote and maintain proper positioning of the spindle and cleavage plane relative to each other.

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Wnt5a signaling controls cytokinesis by correctly positioning ESCRT-III at the midbody.

Wnts activate at least two signaling pathways, the β-catenin-dependent and -independent pathways. Although the β-catenin-dependent pathway is known to contribute to G1-S transition, involvement of the β-catenin-independent pathway in cell cycle regulation remains unclear. Here, we show that Wnt5a signaling, which activates the β-catenin-independent pathway, is required for cytokinesis. Dishevel...

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Cytokinesis in Aspergillus nidulans is controlled by cell size, nuclear positioning and mitosis.

The mycelium of Aspergillus nidulans is composed of multinucleate cellular compartments delimited by crosswalls called septa. Septum formation is dependent on mitosis and requires the recruitment of actin to the site of septum formation. Employing a collection of temperature sensitive nuclear distribution (nudA2, nudC3 and nudF7), nuclear division (nimA5, hfaB3), and septation (sepD5, sepG1) mu...

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ژورنال

عنوان ژورنال: Genes & Development

سال: 2009

ISSN: 0890-9369

DOI: 10.1101/gad.1772009